Tohoku J Exp Med. 1979 Nov;129(3):303-9.

Experimental investigation on the pathogenesis of tartrazine-induced asthma.

Abstract

The effects of tartrazine on the synthesis of prostaglandin-like substances (PGLS) from arachidonic acid in isolated perfused guinea pig lung, and on the contractile responses of guinea pig tracheal tissues induced by histamine, acetylcholine, bradykinin, serotonin and prostaglandin F2 alpha were studied. The synthesis of PGLS from arachidonic acid was not inhibited by tartrazine. The contractile responses of guinea pig tracheal tissues induced by various bronchoconstrictors were potentiated in the presence of tartrazine. These results may suggest that tartrazine-induced asthma is not induced by inhibition of PGLS synthesis, but induced by potentiation of bronchoconstrictor responses.

PMID:: 524353; [PubMed - indexed for MEDLINE]

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[Experimental investigation on pathogenesis of tartrazine-induced asthma (author's transl)]. [Nihon Kyobu Shikkan Gakkai Zas...]
[Experimental investigation on pathogenesis of tartrazine-induced asthma (author's transl)].
Ishihara Y, Asada Y, Kitamura S, Kosaka K, Yamanaka R, Suetsugu S, Sakakibara H, Umeda H. Nihon Kyobu Shikkan Gakkai Zasshi. 1978 Jun; 16(6):435-9.
Effects of tartrazine of different contractile stimuli in guinea pig tracheal muscle. [Acta Pharmacol Toxicol (Copenh...]
Effects of tartrazine of different contractile stimuli in guinea pig tracheal muscle.
Hedman SE, Andersson RG. Acta Pharmacol Toxicol (Copenh). 1981 Feb; 48(2):101-7.
[Experimental investigation on the pathogenesis of aspirin-induced asthma--the effects of aspirin on the contraction of guinea-pig tracheal tissues with various bronchoconstrictors (author's transl)]. [Nihon Kyobu Shikkan Gakkai Zas...]
[Experimental investigation on the pathogenesis of aspirin-induced asthma--the effects of aspirin on the contraction of guinea-pig tracheal tissues with various bronchoconstrictors (author's transl)].
Ishihara Y, Sasaki K, Kitamura S, Kosaka K, Harasawa M. Nihon Kyobu Shikkan Gakkai Zasshi. 1977 Jul; 15(7):380-4.
Is tartrazine-induced asthma related to inhibition of prostaglandin biosynthesis? [Respiration. 1980]
Is tartrazine-induced asthma related to inhibition of prostaglandin biosynthesis?
Vargaftig BB, Bessot JC, Pauli G. Respiration. 1980; 39(5):276-82.
Tartrazine and the prostaglandin system. [J Allergy Clin Immunol. 1979]
Tartrazine and the prostaglandin system.
Gerber JG, Payne NA, Oelz O, Nies AS, Oates JA. J Allergy Clin Immunol. 1979 Apr; 63(4):289-94.

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Experimental investigation on the pathogenesis of tartrazine-induced asthma.

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