J Nat Prod. 1979 Sep-Oct;42(5):483-8.

Cytotoxic principles from the sap of Kalmia latifolia.

Abstract

Examination of the sap of Kalmia latifolia has revealed Grayanotoxin I (1), phloretin (3), and 2',6'-dihydroxy-4-methoxyacetophenone (5) as cytotoxic components. Twenty-one dihydrochalcones have been synthesized and tested for cytotoxic activity. 2'3,3'4,4'-Pentahydroxydihydrochalcone (8) has been found to be cytotoxic and to have marginal activity in vivo. Seven new dihydrochalcones are described.

PMID:: 521818; [PubMed - indexed for MEDLINE]

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Research Support, U.S. Gov't, P.H.S.

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Toxins, Biological

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Cytotoxic principles from the sap of Kalmia latifolia.
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J Nat Prod. 1979 Sep-Oct ;42(5):483-8.

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Cytotoxic principles from the sap of Kalmia latifolia.

Abstract

Publication Types, MeSH Terms, Substances

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