Stereospecificity at carbon 6 of fomyltetrahydrofolate as a competitive inhibitor of transport and cytotoxicity of methotrexate in vitro

Biochem Pharmacol. 1979 Oct 1;28(19):2993-7. doi: 10.1016/0006-2952(79)90599-9.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Survival / drug effects
  • Formyltetrahydrofolates / pharmacology*
  • Kinetics
  • Leukemia L1210 / metabolism
  • Methotrexate / antagonists & inhibitors*
  • Methotrexate / metabolism
  • Mice
  • Mice, Inbred Strains
  • Molecular Conformation
  • Stereoisomerism
  • Structure-Activity Relationship
  • Tetrahydrofolates / pharmacology*
  • Time Factors

Substances

  • Formyltetrahydrofolates
  • Tetrahydrofolates
  • Methotrexate