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    Haemostasis. 1979;8(3-5):227-33.

    Lipid metabolism, atherogenesis, and haemostasis in Eskimos: the role of the prostaglandin-3 family.

    Abstract

    In Eskimos coronary heart disease is a rarity. This can partly be explained by their favorable plasma lipid levels. An additional factor seems, however, to be that in Eskimo food polyunsaturated fatty acids of the omega-3 series replace those of the omega-6 series. C20:5, omega-3 can be converted by the vessel wall to an antiaggregatory substance, whereas it has no proaggregatory effect on platelets. Consistent with these findings Eskimos were found to have a nearly 2-fold longer bleeding time than Danes. Platelet aggregability, too, was markedly depressed when exposing platelets from Eskimos to ADP and collagen.

    PMID:
    511010
    [PubMed - indexed for MEDLINE]

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