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    Drug Alcohol Depend. 1979 Sep;4(5):435-8.

    Methamphetamine-induced changes in brain catecholamines in rats and guinea pigs.

    Abstract

    Repeated administration of methamphetamine was found to cause long-term changes in caudate dopamine levels in the rat and guinea pig. Methamphetamine was administered twice a day for thirty days. Two weeks following the last injection, the animals were killed and brains assayed for catecholamine content. These long-term depletions of dopamine, when combined with similar observations previously reported in rhesus monkeys, indicate a species generality of the effects of methamphetamine on caudate dopamine levels.

    PMID:
    510182
    [PubMed - indexed for MEDLINE]

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