Clin Orthop Relat Res. 1975 Sep;(111):14-22.

The etiology of osteosarcoma. A review of current considerations.

Abstract

Various agents have caused osteosarcoma in several experimental animal systems. These agents or initiators may be classified as chemicals, radiation, viruses, and miscellaneous. Zinc beryllium silicate with beryllium oxide in rabbits and FBJ virus in mice are two such initiating agents. The relevance of these animal experiments to the human situation is not known, but recent reports regarding a transmissible agent obtained from human osteosarcoma tissue suggest that a virus may be implicated. There is a theoretic indication that the various etiologic agents, including viruses, may affect the DNA of normal cells in such a way that further evolution and differentiation through several cell divisions may result in the clinical appearance of cancer.

PMID:: 50894; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Ovid Technologies, Inc.

Medical

Bone Cancer - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Pathogenesis of radiation and virus-induced bone tumors. [Recent Results Cancer Res. 1976]
Pathogenesis of radiation and virus-induced bone tumors.
Finkel MP, Reilly CA Jr, Biskis BO. Recent Results Cancer Res. 1976; (54):92-103.
[Viral etiology of some osteogenic osteosarcomas. Critical review]. [Bull Cancer. 1971]
[Viral etiology of some osteogenic osteosarcomas. Critical review].
Latarjet R. Bull Cancer. 1971 Apr-Jun; 58(2):277-86.
Radiation dose, chemotherapy and risk of osteosarcoma after solid tumours during childhood. [Int J Cancer. 1998]
Radiation dose, chemotherapy and risk of osteosarcoma after solid tumours during childhood.
Le Vu B, de Vathaire F, Shamsaldin A, Hawkins MM, Grimaud E, Hardiman C, Diallo I, Vassal G, Bessa E, Campbell S, et al. Int J Cancer. 1998 Jul 29; 77(3):370-7.
Review Etiology of osteosarcoma. [Clin Orthop Relat Res. 2002]
Review Etiology of osteosarcoma.
Fuchs B, Pritchard DJ. Clin Orthop Relat Res. 2002 Apr; (397):40-52.
Review [The combined action of ionizing radiation and carcinogens]. [Vopr Onkol. 1969]
Review [The combined action of ionizing radiation and carcinogens].
Kondrat'eva AF. Vopr Onkol. 1969; 15(3):109-18.

See reviews... See all...

Cited by 2 PubMed Central articles

Neoplasms in domestic animals: a review of experimental and spontaneous carcinogenesis. [Yale J Biol Med. 1981]
Neoplasms in domestic animals: a review of experimental and spontaneous carcinogenesis.
Madewell BR. Yale J Biol Med. 1981 Mar-Apr; 54(2):111-25.
Animal model of human disease. Skeletal hyperostoses: viral induction of avian osteopetrosis. [Am J Pathol. 1982]
Animal model of human disease. Skeletal hyperostoses: viral induction of avian osteopetrosis.
Schmidt EV, Smith RE. Am J Pathol. 1982 Feb; 106(2):297-9.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

The etiology of osteosarcoma. A review of current considerations.
The etiology of osteosarcoma. A review of current considerations.
Clin Orthop Relat Res. 1975 Sep ;(111):14-22.

PubMed
The Dubowitz syndrome.
The Dubowitz syndrome.
Z Kinderheilkd. 1971 ;110(3):175-87.

PubMed
Pulmonary resection in infants younger than one year of age.
Pulmonary resection in infants younger than one year of age.
J Thorac Cardiovasc Surg. 1971 Jun ;61(6):875-81.

PubMed
Tarsal-tunnel syndrome. Review of the literature and two case reports.
Tarsal-tunnel syndrome. Review of the literature and two case reports.
Clin Orthop Relat Res. 1972 ;88:76-9.

PubMed
Silicon: an essential element for the chick.
Silicon: an essential element for the chick.
Science. 1972 Nov 10 ;178(4061):619-21.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The etiology of osteosarcoma. A review of current considerations.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information