Format

Send to

Choose Destination
See comment in PubMed Commons below
J Physiol. 1972 Jun;223(3):803-14.

The effects of anaesthetics on synaptic excitation and inhibition in the olfactory bulb.

Abstract

1. The effects of anaesthetics (pentobarbitone, hexobarbitone, halothane, urethane, chloralose, chloral hydrate and ethanol) on the extracellular field potentials of the olfactory bulb produced by lateral olfactory tract stimulation were analysed.2. Relatively large doses of all the anaesthetics (e.g. pentobarbitone, 40-70 mg/kg) depressed the synaptic excitation of granule cells.3. The antidromic invasion of mitral cell dendrites was only slightly less sensitive to the anaesthetics than was the synaptic excitation of granule cells.4. A wide dose range of anaesthetics (e.g. pentobarbitone, 3-60 mg/kg) prolonged the granule cell post-synaptic inhibition of mitral cells. All the anaesthetics, except ethanol, prolonged the inhibition.5. The action of anaesthetics on post-synaptic inhibition was due to a specific effect on the inhibitory synapses.6. Amino-oxyacetic acid, an inhibitor of GABA catabolism, had little effect on the synaptic inhibition or on the ability of hexobarbital to prolong the inhibition. This suggests that the prolongation seen with anaesthetics is not a result of interfering with GABA catabolism.7. The present results are compared with results obtained with anaesthetics in other areas of the nervous system and it is proposed that prolongation of ;gaba-ergic' inhibition might contribute to an agent's ability to produce general anaesthesia.

PMID:
5045741
PMCID:
PMC1331482
[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Write to the Help Desk