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C R Acad Sci Hebd Seances Acad Sci D. 1975 May 12;280(18):2141-3.

[In vivo study of the hypocalcemic, hypophosphoremic, hyperlipemic, and immunogenic activities of the oligopeptide fragment common to ACTH, alpha and beta MSH, and beta lipotropin].

[Article in French]


The intravenous injection that was given to rabbits which consisted of 0,5 mg of a common heptapeptide to ACTH4-10, BETA MSH11-17 hormones, and to beta lipotropic47-53 hormone (beta LPH47-53) was followed at the end of an hour by an augmentation of 70% of total lipids, and at the end of two hours by a lowering of calcemia (around 27%) and of phosphoremia (20%). The injection of a tetrapeptide corresponding to only ACTH7-10 bound to a nitrobenzylhydralamin and in presence of a Freund adjuvants has provoked the formation of corresponding antibodies.

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