J Cutan Pathol. 1979 Aug;6(4):243-52.

"Lumpy-bumpy" elastic fibers in the skin and lungs of a patient with a penicillamine-induced elastosis perforans serpiginosa.

Abstract

Penicillamine-induced cutaneous elastosis perforans serpiginosa associated with a large air-cyst in the right lung is described in a 29-year-old female patient with Wilson disease. Identical light and electron-microscopic changes were present in both dermal and pulmonary elastic tissue, suggesting a disseminated drug-induced cutaneo-visceral elastosis. Lung cysts have not been previously reported in association with long term penicillamine treatment. The electron-microscopic morphology of the elastic fibers was found to be "specific" enough to allow separation of penicillamine-induced elastosis perforans serpiginosa from other forms of this disease.

PMID:: 500870; [PubMed - indexed for MEDLINE]

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Penicillamine

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[Penicillamine-induced elastosis perforans serpiginosa and pulmonary cyst in Wilson's disease (author's transl)]. [Wien Klin Wochenschr. 1981]
[Penicillamine-induced elastosis perforans serpiginosa and pulmonary cyst in Wilson's disease (author's transl)].
Bardach H, Gebhart W, Niebauer G, Bardach G. Wien Klin Wochenschr. 1981 Feb 20; 93(4):117-22.
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Cited by 3 PubMed Central articles

Penicillamine-induced Elastosis Perforans Serpiginosa and Cutis Laxa in a Patient with Wilson's Disease. [Ann Dermatol. 2010]
Penicillamine-induced Elastosis Perforans Serpiginosa and Cutis Laxa in a Patient with Wilson's Disease.
Na SY, Choi M, Kim MJ, Lee JH, Cho S. Ann Dermatol. 2010 Nov; 22(4):468-71. Epub 2010 Nov 5.
A case of systemic pseudo-pseudoxanthoma elasticum with diverse symptomatology caused by long-term penicillamine use. [J Clin Pathol. 1998]
A case of systemic pseudo-pseudoxanthoma elasticum with diverse symptomatology caused by long-term penicillamine use.
Coatesworth AP, Darnton SJ, Green RM, Cayton RM, Antonakopoulos GN. J Clin Pathol. 1998 Feb; 51(2):169-71.
Pseudoxanthoma elasticum-like skin changes induced by penicillamine. [J R Soc Med. 1984]
Pseudoxanthoma elasticum-like skin changes induced by penicillamine.
Meyrick Thomas RH, Light N, Stephens AD, Avery NC, Kirby JD. J R Soc Med. 1984 Sep; 77(9):794-8.

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