Biometrics. 1979 Mar;35(1):183-97.

Allocation of patients to treatment in clinical trials.

Abstract

This article is intended as a practical guide to the various methods of patient assignment in clinical trials. Topics discussed include a critical appraisal of non-randomized studies, methods of restricted randomization such as random permuted blocks and the biased coin technique, the extent to which stratification is necessary and the methods available, the possible benefits of randomization with a greater proportion of patients on a new treatment, factorial designs, crossover designs, randomized consent designs and adaptive assignment procedures. With all this diversity of approach it needs to be remembered that the effective implementation and reliability of a relatively straightforward randomization scheme may be more important than attempting theoretical optimality with more complex designs.

PMID:: 497334; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

Comparative Study

MeSH Terms

LinkOut - more resources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Clinical Trials - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Bayesian adaptive biased-coin designs for clinical trials with normal responses. [Biometrics. 2005]
Bayesian adaptive biased-coin designs for clinical trials with normal responses.
Atkinson AC, Biswas A. Biometrics. 2005 Mar; 61(1):118-25.
Properties of the urn randomization in clinical trials. [Control Clin Trials. 1988]
Properties of the urn randomization in clinical trials.
Wei LJ, Lachin JM. Control Clin Trials. 1988 Dec; 9(4):345-64.
Designing for cancer clinical trials: selection of prognostic factors. [Cancer Treat Rep. 1980]
Designing for cancer clinical trials: selection of prognostic factors.
Brown BW Jr. Cancer Treat Rep. 1980 Feb-Mar; 64(2-3):499-502.
Review Randomization in substance abuse clinical trials. [Subst Abuse Treat Prev Policy....]
Review Randomization in substance abuse clinical trials.
Hedden SL, Woolson RF, Malcolm RJ. Subst Abuse Treat Prev Policy. 2006 Feb 6; 1:6. Epub 2006 Feb 6.
Review Adaptive design methods in clinical trials - a review. [Orphanet J Rare Dis. 2008]
Review Adaptive design methods in clinical trials - a review.
Chow SC, Chang M. Orphanet J Rare Dis. 2008 May 2; 3:11. Epub 2008 May 2.

See reviews... See all...

Cited by 20 PubMed Central articles

Two-way minimization: a novel treatment allocation method for small trials. [PLoS One. 2011]
Two-way minimization: a novel treatment allocation method for small trials.
Chen LH, Lee WC. PLoS One. 2011; 6(12):e28604. Epub 2011 Dec 7.
Low omega-6 vs. low omega-6 plus high omega-3 dietary intervention for chronic daily headache: protocol for a randomized clinical trial. [Trials. 2011]
Low omega-6 vs. low omega-6 plus high omega-3 dietary intervention for chronic daily headache: protocol for a randomized clinical trial.
Ramsden CE, Mann JD, Faurot KR, Lynch C, Imam ST, MacIntosh BA, Hibbeln JR, Loewke J, Smith S, Coble R, et al. Trials. 2011 Apr 15; 12:97. Epub 2011 Apr 15.
A simulation study of the validity and efficiency of design-adaptive allocation to two groups in the regression situation. [Int J Biostat. 2009]
A simulation study of the validity and efficiency of design-adaptive allocation to two groups in the regression situation.
Aickin M. Int J Biostat. 2009 May 29; 5(1):Article 19. Epub 2009 May 29.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Allocation of patients to treatment in clinical trials.
Allocation of patients to treatment in clinical trials.
Biometrics. 1979 Mar ;35(1):183-97.

PubMed
Differences of cerebral lateralization among schizophrenic and depressed patient...
Differences of cerebral lateralization among schizophrenic and depressed patients.
Biol Psychiatry. 1979 Oct ;14(5):721-33.

PubMed
Pathogenesis of oedema of the optic disc.
Pathogenesis of oedema of the optic disc.
Doc Ophthalmol. 1968 ;24(2):289-411.

PubMed
An investigation of three patients with Christmas disease due to an abnormal typ...
An investigation of three patients with Christmas disease due to an abnormal type of factor IX.
J Clin Pathol. 1968 Mar ;21(2):160-5.

PubMed
Haemoglobin J Paris in the south of Portugal (Algarve).
Haemoglobin J Paris in the south of Portugal (Algarve).
Acta Haematol. 1968 ;39(5):291-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: