Antibodies to deoxyribonucleic acid irradiated with ultraviolet light: detection by precipitins and immunofluorescence

Science. 1968 Sep 27;161(3848):1353-4. doi: 10.1126/science.161.3848.1353.

Abstract

Two rabbits were immunized with a complex consisting of ultravioietirradiated DNA and methylated bovine serum albumin. Serum antibodies reacted only with irradiated DNA, and the serological reaction was shown by immuneprecipitation and immunofluorescence.

MeSH terms

  • Animals
  • Antibodies*
  • Chemical Precipitation
  • DNA / radiation effects*
  • Fluorescent Antibody Technique
  • Hot Temperature
  • Immune Sera
  • Immunodiffusion
  • Lupus Erythematosus, Systemic / immunology
  • Methylation
  • Nucleic Acid Denaturation
  • Precipitin Tests
  • Rabbits
  • Radiation Effects
  • Radiochemistry
  • Serum Albumin, Bovine
  • Thymus Gland
  • Ultraviolet Rays*

Substances

  • Antibodies
  • Immune Sera
  • Serum Albumin, Bovine
  • DNA