Water, protein folding, and the genetic code

Science. 1979 Nov 2;206(4418):575-7. doi: 10.1126/science.493962.

Abstract

The absolute affinities of amino acid side chains for solvent water closely match their relative distributions between the surface and the interior of native proteins and are associated with a remarkable bias in the genetic code.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acids / genetics*
  • Genetic Code*
  • Mutation
  • Protein Conformation
  • Solubility
  • Thermodynamics
  • Water

Substances

  • Amino Acids
  • Water