Diabetes. 1979 Nov;28(11):1031-2.

Spontaneous diabetes in the gnotobiotic BB/W rat.

Rossini AA, Williams RM, Mordes JP, Appel MC, Like AA.

Abstract

To determine the influence of infectious agents on the initiation of diabetes in the spontaneously diabetic Bio-Breeding/Worcester (BB/W) rat, susceptible rats were raised in a germ-free environment. Between 2 and 3 mo of age, 3 of 12 pups became diabetic. Histologic examination of the pancreas revealed insulitis or end-stage islets. Culture and smears from various tissues were negative for bacteria or parasites. Serum vital antibody titers for all known rat viruses were undetectable. These data suggest that the diabetic syndrome of the BB/W rat is not dependent on recognized infectious agents.

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[An experimental study of spontaneously diabetic Bio Breeding/Worcester (BB/W) rats--with special references to the rat MHC (RT1) in the development of the disease]. [Hokkaido Igaku Zasshi. 1989]
[An experimental study of spontaneously diabetic Bio Breeding/Worcester (BB/W) rats--with special references to the rat MHC (RT1) in the development of the disease].
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Cited by 6 PubMed Central articles

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Seemayer TA, Tannenbaum GS, Goldman H, Colle E. Am J Pathol. 1982 Feb; 106(2):237-49.
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