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Eur J Pharmacol. 1979 Aug 15;57(4):427-30.

Serotonin release is modulated by presynaptic autoreceptors.

Abstract

The existence of presynaptic autoreceptors controlling the release of 5-hydroxytryptamine (5HT) from serotonergic nerve endings was investigated utilizing superfused hypothalamic synaptosomes. Extracellular 5HT reduced the high K+-induced release of previously accumulated 3H-5HT. The central 5HT receptor blocker methiothepin counteracted the inhibitory effect of 5HT. Other 5HT antagonists (cyproheptadine, methysergide and mianserin) were inactive and may therefore act preferentially at the postsynaptic receptors.

PMID:
488172
[PubMed - indexed for MEDLINE]
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