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J Neurol Neurosurg Psychiatry. 1974 Apr;37(4):416-20.

L-dopa and arousal.

Abstract

In 10 patients with Parkinsonism, treatment with L-dopa was associated with a rise in the skin conductance level and its fluctuations, an increased electromyographic activity in the frontalis muscle, and with faster reaction times. The change of skin conductance in response to a loud noise also increased and its habituation to the repetition of the stimulus was delayed. One patient developed a schizophreniform psychosis and showed high arousal and absent habituation. It is possible that dopamine is the transmitter associated with the arousal reaction and that it plays a part in the pathogenesis of schizophrenia.

PMID:
4838912
[PubMed - indexed for MEDLINE]
PMCID:
PMC494672
Free PMC Article
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