Abstract
A proteolipid isolated from a lipid extract of mouse brain demonstrates stereospecific binding properties for levorphanol. It is present only in neuronal tissue and most abundant in the rhombencephalon. One component saturates at a concentration corresponding to maximum pharmacologic effect in vivo. The estimated mass is 60,000 daltons per bound opiate molecule.
MeSH terms
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Animals
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Binding Sites
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Binding, Competitive
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Brain / metabolism*
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Brain Chemistry*
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Brain Stem / metabolism
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Carbon Radioisotopes
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Cerebellum / metabolism
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Chloroform
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Chromatography, Gel
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Kidney / metabolism
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Kinetics
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Levorphanol / antagonists & inhibitors
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Levorphanol / metabolism*
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Lipoproteins / isolation & purification*
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Lipoproteins / metabolism
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Liver / metabolism
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Methanol
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Mice
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Molecular Weight
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Morphinans / metabolism
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Muscles / metabolism
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Naloxone / pharmacology
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Receptors, Drug*
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Tissue Extracts
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Tritium
Substances
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Carbon Radioisotopes
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Lipoproteins
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Morphinans
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Receptors, Drug
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Tissue Extracts
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Tritium
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Levorphanol
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Naloxone
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Chloroform
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Methanol