N Engl J Med. 1979 Oct 25;301(17):901-5.

Protection of granulocytes by vitamin E in glutathione synthetase deficiency.

Boxer LA, Oliver JM, Spielberg SP, Allen JM, Schulman JD.

Abstract

The administration of vitamin E (alpha-tocopherol) was found to improve polymorphonuclear leukocyte function in an infant with congenital deficiency of glutathione synthetase activity. Before therapy with vitamin E the abnormal leukocytes exposed to phagocytic challenge showed oxidant damage. They released 60 per cent more hydrogen peroxide than did normal leukocytes, iodinated only 20 to 25 per cent of the normal number of particles, and were unable to kill bacteria as effectively as normal leukocytes although the rates of phagocytosis were normal. These functional abnormalities disappeared when the patient was placed on 400 IU of alpha-tocopherol daily for three months. Associated with the functional improvement was a normalization of microtubule assembly during phagocytic challenge.

PMID:: 481537; [PubMed - indexed for MEDLINE]

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Microtubule assembly and function in normal and glutathione synthetase-deficient polymorphonuclear leukocytes. [J Immunol. 1978]
Microtubule assembly and function in normal and glutathione synthetase-deficient polymorphonuclear leukocytes.
Oliver JM, Spielberg SP, Pearson CB, Schulman JD. J Immunol. 1978 Apr; 120(4):1181-6.
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Protection of granulocytes by vitamin E in glutathione synthetase deficiency.

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