Hypothalamic polypeptide that inhibits the secreti...[Science. 1973]

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1: Science. 1973 Jan 5;179(68):77-9. Links

Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone.

Brazeau P, Vale W, Burgus R, Ling N, Butcher M, Rivier J, Guillemin R.

A peptide has been isolated from ovine hypothalamus which, at 1 x 10(-9)M, inhibits secretion in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in rats. Its structure is H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH The synthetic replicate is biologically active.

PMID: 4682131 [PubMed - indexed for MEDLINE]

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