Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Hyg (Lond). 1973 Dec;71(4):641-7.

The efficacy of live and inactivated vaccines of Hong Kong influenza virus in an industrial community. A report to the Medical Research Council Committee on influenza and other respiratory virus vaccines.

Abstract

Intranasal vaccines of inactivated or living attentuated A2/Hong Kong influenza viruses were compared for clinical acceptability, serological effects and protective efficiency against natural epidemic influenza in a large industrial and clerical population.Neither vaccine resulted in any significant untoward side-effects. The serum haemagglutination-inhibiting (HI) antibody response within 1 month of vaccination was similar with both vaccines; approximately 50% of those with little or no pre-vaccination antibody developed 4-fold or greater rises in titre. The effect of the antigenic potency of the vaccines and the prior immunological experience of the population is discussed. Volunteers given live vaccine showed a 2.2-fold lower incidence of clinical influenza than those given killed vaccine in a natural epidemic 16 months after vaccination.

PMID:
4588772
[PubMed - indexed for MEDLINE]
PMCID:
PMC2130408
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk