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Proc Natl Acad Sci U S A. 1973 Dec;70(12):3581-4.

The nucleotide sequence of the lac operator.

Abstract

The lac repressor protects the lac operator against digestion with deoxyribonuclease. The protected fragment is double-stranded and about 27 base-pairs long. We determined the sequence of RNA transcription copies of this fragment and present a sequence for 24 base pairs. It is: 5'--T G G A A T T G T G A G C G G A T A A C A A T T 3' 3'--A C C T T A A C A C T C G C C T A T T G T T A A 5' The sequence has 2-fold symmetry regions; the two longest are separated by one turn of the DNA double helix.

PMID:
4587255
[PubMed - indexed for MEDLINE]
PMCID:
PMC427284
Free PMC Article
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