Quinazolines and 1,4-benzodiazepines. LXXXIX: Hapt...[J Pharm Sci. 1979]

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1: J Pharm Sci. 1979 Jul;68(7):845-50.Links

Quinazolines and 1,4-benzodiazepines. LXXXIX: Haptens useful in benzodiazepine immunoassay development.

Earley JV, Fryer RI, Ning RY.

The syntheses of some 1,4-benzodiazepines potentially useful as haptens are reported. These compounds are related to chlordiazepoxide, diazepam, nitrazepam, clonazepam, and some of their metabolites. The chemistry reported here is intended to support specific immunoassay development for these drugs.

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Diazepam (Diazepam Intensol® , Valium® )
Diazepam is used to relieve anxiety, muscle spasms, and seizures and to control agitation caused by alcohol withdrawal.
Chlordiazepoxide (Librium® , Limbitrol® , Limbitrol® DS)
Chlordiazepoxide is used to relieve anxiety and to control agitation caused by alcohol withdrawal.
Clonazepam (Klonopin® )
Clonazepam is used alone or in combination with other medications to control certain types of seizures. It is also used to relieve panic attacks (sudden, unexpected attacks of extreme fear and worry about these attacks)....
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