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Proc Natl Acad Sci U S A. 1973 Jul;70(7):2046-50.

A genetic method for determining the order of events in a biological pathway.

Abstract

We describe the application of a simple genetic test that indicates the order of events in a morphogenic or biochemical pathway. The test uses temperature-sensitive (ts) and cold-sensitive (cs) mutants, and it orders the times at which the ts and cs defects are expressed.

PMID:
4579012
[PubMed - indexed for MEDLINE]
PMCID:
PMC433662
Free PMC Article
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