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Proc Natl Acad Sci U S A. 1974 Oct;71(10):4198-202.

Stability of neuronal microtubules to high pressure in vivo and in vitro.

Abstract

Neuronal microtubules in a variety of nerve cell types are unaffected by high hydrostatic pressures over a range of 1400-10,000 pounds/inch(2) and periods of 10-45 min. Similarly, purified tubulin polymerized to form microtubules in vitro were not depolymerized by the same range of pressures. The depolymerization of microtubules in several types of non-neuronal cells, which has been reported, may have been over-generalized with regard to the direct action of pressure on microtubule stability.

PMID:
4547844
[PubMed - indexed for MEDLINE]
PMCID:
PMC434357
Free PMC Article
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