Arch Neurol. 1979 Jul;36(7):410-6.

Effects of advancing age on regional cerebral blood flow. Studies in normal subjects and subjects with risk factors for atherothrombotic stroke.

Naritomi H, Meyer JS, Sakai F, Yamaguchi F, Shaw T.

Abstract

Regional cerebral blood flow (rCBF) was measured by 133Xe inhalation in 46 normal volunteers, aged 21 to 63 years, and 14 neurologically asymptomatic subjects above age 40 with risk factors for atherothrombotic stroke, including hypertension, diabetes mellitus, and hyperlipidemia. In normal volunteers, there was diffuse and progresive reduction of gray matter flow and weight as well as increases of cerebrovascular resistance (CVR) with advancing age. Reduction of gray matter flow with advancing age appears to be attributed in part to neuronal atrophy and in part to cerebral arteriosclerosis. Regional increases of CVR and reduction of gray matter flow with advancing age were most evident in the middle cerebral arterial (MCA) distribution and were enhanced by the association of risk factors. Development of cerebral arteriosclerosis with age and/or risk factors appears to be most evident in MCA distribution.

PMID:: 454246; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

Xenon Radioisotopes

LinkOut - more resources

Full Text Sources

Medical

Seniors' Health - MedlinePlus Health Information

Supplemental Content

Icon for Silverchair Information Systems

Save items

Related citations in PubMed

[Age-matched normal values of regional cerebral blood flow measurements by 133Xe inhalation and production of judgment image: as to initial slope index computed by Fourier analysis]. [No To Shinkei. 1982]
[Age-matched normal values of regional cerebral blood flow measurements by 133Xe inhalation and production of judgment image: as to initial slope index computed by Fourier analysis].
Matsuda H, Maeda T, Yamada M, Gui LX, Hisada K. No To Shinkei. 1982 Nov; 34(11):1091-7.
Cigarette smoking decreases cerebral blood flow suggesting increased risk for stroke. [JAMA. 1983]
Cigarette smoking decreases cerebral blood flow suggesting increased risk for stroke.
Rogers RL, Meyer JS, Shaw TG, Mortel KF, Hardenberg JP, Zaid RR. JAMA. 1983 Nov 25; 250(20):2796-800.
Stable xenon CT CBF measurements in prevalent cerebrovascular disorders (stroke). [Stroke. 1984]
Stable xenon CT CBF measurements in prevalent cerebrovascular disorders (stroke).
Meyer JS, Okayasu H, Tachibana H, Okabe T. Stroke. 1984 Jan-Feb; 15(1):80-90.
Review Stroke and the aging of the brain and the arteries. [Geriatrics. 1998]
Review Stroke and the aging of the brain and the arteries.
Ramirez-Lassepas M. Geriatrics. 1998 Sep; 53 Suppl 1:S44-8.
Review Neuroimaging in cerebrovascular disorders: measurement of cerebral physiology after stroke and assessment of stroke recovery. [Semin Nucl Med. 2003]
Review Neuroimaging in cerebrovascular disorders: measurement of cerebral physiology after stroke and assessment of stroke recovery.
Mountz JM, Liu HG, Deutsch G. Semin Nucl Med. 2003 Jan; 33(1):56-76.

See reviews... See all...

Cited by 5 PubMed Central articles

Review Metabolic agents that enhance ATP can improve cognitive functioning: a review of the evidence for glucose, oxygen, pyruvate, creatine, and L-carnitine. [Nutrients. 2011]
Review Metabolic agents that enhance ATP can improve cognitive functioning: a review of the evidence for glucose, oxygen, pyruvate, creatine, and L-carnitine.
Owen L, Sunram-Lea SI. Nutrients. 2011 Aug; 3(8):735-55. Epub 2011 Aug 10.
Epidemiology of stroke in chronic heart failure patients with normal sinus rhythm: findings from the DIG stroke sub-study. [Int J Cardiol. 2010]
Epidemiology of stroke in chronic heart failure patients with normal sinus rhythm: findings from the DIG stroke sub-study.
Mujib M, Giamouzis G, Agha SA, Aban I, Sathiakumar N, Ekundayo OJ, Zamrini E, Allman RM, Butler J, Ahmed A. Int J Cardiol. 2010 Oct 29; 144(3):389-93. Epub 2009 May 12.
Alcohol consumption and cerebral blood flow among older adults. [Alcohol. 2008]
Alcohol consumption and cerebral blood flow among older adults.
Christie IC, Price J, Edwards L, Muldoon M, Meltzer CC, Jennings JR. Alcohol. 2008 Jun; 42(4):269-75.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Effects of advancing age on regional cerebral blood flow. Studies in normal subj...
Effects of advancing age on regional cerebral blood flow. Studies in normal subjects and subjects with risk factors for atherothrombotic stroke.
Arch Neurol. 1979 Jul ;36(7):410-6.

PubMed
Detection of heterozygotes for recessive von Willebrand's disease by the assay o...
Detection of heterozygotes for recessive von Willebrand's disease by the assay of antihemophilic-factor-like antigen.
N Engl J Med. 1973 Oct 25 ;289(17):882-5.

PubMed
Aldose reductase in diabetic complications of the eye.
Aldose reductase in diabetic complications of the eye.
Metabolism. 1979 Apr ;28(4 Suppl 1):462-9.

PubMed
Stimulation of human prolactin secretion by intravenous infusion of L-tryptophan...
Stimulation of human prolactin secretion by intravenous infusion of L-tryptophan.
J Clin Invest. 1973 Aug ;52(8):1972-8.

PubMed
Patient and physician attitudes toward lithium: relationship to compliance.
Patient and physician attitudes toward lithium: relationship to compliance.
Arch Gen Psychiatry. 1979 Jul 20 ;36(8 Spec No):866-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: