The effect of replacement of methionine by homocystine on survival of malignant and normal adult mammalian cells in culture

Proc Natl Acad Sci U S A. 1974 Apr;71(4):1133-6. doi: 10.1073/pnas.71.4.1133.

Abstract

In tissue cultures of normal adult and malignant mammalian cells, homocystine has been substituted for methionine in a medium rich in folic acid and cyanocobalamin. Normal adult cells thrive. Three highly malignant cell types from three different species, including man, die.

MeSH terms

  • Animals
  • Breast
  • Carcinoma 256, Walker / metabolism*
  • Cell Division / drug effects
  • Cell Line
  • Cell Survival
  • Cells, Cultured / metabolism*
  • Culture Media
  • Female
  • Fibroblasts
  • Folic Acid / metabolism
  • Homocystine / metabolism*
  • Humans
  • Leukemia L1210
  • Leukemia, Experimental
  • Leukemia, Myeloid
  • Liver
  • Male
  • Methionine / metabolism*
  • Mice
  • Prostate
  • Rats
  • Vitamin B 12 / metabolism

Substances

  • Culture Media
  • Homocystine
  • Folic Acid
  • Methionine
  • Vitamin B 12