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Proc Natl Acad Sci U S A. 1973 Jan;70(1):10.

Methadone plasma level: sustained by a reservoir of drug in tissue.

Abstract

Binding of methadone in body tissues limits the rise in plasma concentration and prolongs the pharmacological action in patients receiving a daily maintenance dose. An opiate with equal intrinsic activity but greater binding affinity would, therefore, be a better drug than methadone for maintenance treatment; it would be safer when taken in a single dose and longer in its duration of action when taken on a regular schedule.

PMID:
4509643
[PubMed - indexed for MEDLINE]
PMCID:
PMC433171
Free PMC Article
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