Proc Natl Acad Sci U S A. 1969 Mar;62(3):756-63.

D-amino acid oxidase in leukocytes: a possible D-amino-acid-linked antimicrobial system.

Abstract

D-Amino acid oxidase has been identified within the granule fraction of human neutrophilic leukocytes. Leukocyte homogenates and purified kidney D-amino acid oxidase can utilize either isolated D-amino acids or some species of bacteria as substrates for the generation of hydrogen peroxide. When linked to leukocyte myeloperoxidase in vitro, purified D-amino acid oxidase constitutes a system lethal for certain bacteria. It is proposed that leukocyte D-amino acid oxidase and myeloperoxidase constitute a biochemically specific system for the recognition and killing of certain microorganisms.

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Cited by 12 PubMed Central articles

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D-amino acid oxidase in leukocytes: a possible D-amino-acid-linked antimicrobial...
D-amino acid oxidase in leukocytes: a possible D-amino-acid-linked antimicrobial system.
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D-amino acid oxidase in leukocytes: a possible D-amino-acid-linked antimicrobial system.

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