Biochem J. 1973 May;133(1):11-3.

Confirmation of the 1-20 amino acid sequence of human adrenocorticotrophin.

Abstract

The tryptic fragments of natural human adrenocorticotrophin, were separated by countercurrent distribution and a correction in positions 25, 26, 27 and 30 was made by Riniker et al. (1972) in a study of the fragment containing residues 22-39. We have purified the remaining tryptic fragments, namely residues 1-8, 9-15, 16-21 and 17-21, by using ion-exchange chromatography on CM-cellulose and have carried out sequence determination by using the subtractive Edman degradation procedure and digestion with aminopeptidase M and carboxypeptidase B. These results have confirmed the proposed sequence for human adrenocorticotrophin in regions 6-7, 10-14 and 17-20, which had previously been arrived at only by analogy with the invariant sequence found in the three other mammalian adrenocorticotrophin species that had been investigated.

PMID:: 4352834; [PubMed - indexed for MEDLINE]
PMCID:: PMC1177665

Free PMC Article

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Corticotropin - HSDB

Supplemental Content

Save items

Related citations in PubMed

Identity of structure of ovine and bovine ACTH: correction of revised structure of the ovine hormone. [FEBS Lett. 1974]
Identity of structure of ovine and bovine ACTH: correction of revised structure of the ovine hormone.
Jöhl A, Riniker B, Schenkel-Hulliger L. FEBS Lett. 1974 Sep 1; 45(1):172-4.
Re-examination of the sequence of the C-terminal tryptic fragment from porcine adrenocorticotropic hormone. [Acta Biochim Biophys Acad Sci ...]
Re-examination of the sequence of the C-terminal tryptic fragment from porcine adrenocorticotropic hormone.
Gráf L. Acta Biochim Biophys Acad Sci Hung. 1972; 7(4):293-7.
Vitamin K and the biosynthesis of prothrombin. V. Gamma-carboxyglutamic acids, the vitamin K-dependent structures in prothrombin. [J Biol Chem. 1975]
Vitamin K and the biosynthesis of prothrombin. V. Gamma-carboxyglutamic acids, the vitamin K-dependent structures in prothrombin.
Fernlund P, Stenflo J, Roepstorff P, Thomsen J. J Biol Chem. 1975 Aug 10; 250(15):6125-33.
Review Sequence determination. [Mol Biol Biochem Biophys. 1970]
Review Sequence determination.
Edman P. Mol Biol Biochem Biophys. 1970; 8:211-55.
Review End group determination. [Mol Biol Biochem Biophys. 1970]
Review End group determination.
Narita K. Mol Biol Biochem Biophys. 1970; 8:25-90.

See reviews... See all...

Cited by 4 PubMed Central articles

NH2-terminal amino acid sequence and peptide mapping of purified human beta-lipotropin: comparison with previously proposed sequences. [Proc Natl Acad Sci U S A. 1982]
NH2-terminal amino acid sequence and peptide mapping of purified human beta-lipotropin: comparison with previously proposed sequences.
Spiess J, Mount CD, Nicholson WE, Orth DN. Proc Natl Acad Sci U S A. 1982 Aug; 79(16):5071-5.
The isolation and amino acid sequence of an adrenocorticotrophin from the pars distalis and a corticotrophin-like intermediate-lobe peptide from the neurointermediate lobe of the pituitary of the dogfish Squalus acanthias. [Biochem J. 1974]
The isolation and amino acid sequence of an adrenocorticotrophin from the pars distalis and a corticotrophin-like intermediate-lobe peptide from the neurointermediate lobe of the pituitary of the dogfish Squalus acanthias.
Lowry PJ, Bennett HP, McMartin C. Biochem J. 1974 Aug; 141(2):427-37.
Adrenocorticotrophic and melanocyte-stimulating peptides in the human pituitary. [Biochem J. 1974]
Adrenocorticotrophic and melanocyte-stimulating peptides in the human pituitary.
Scott AP, Lowry PJ. Biochem J. 1974 Jun; 139(3):593-602.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Confirmation of the 1-20 amino acid sequence of human adrenocorticotrophin.
Confirmation of the 1-20 amino acid sequence of human adrenocorticotrophin.
Biochem J. 1973 May ;133(1):11-3.

PubMed
[Reconstructive surgery in congenital thumb anomalies].
[Reconstructive surgery in congenital thumb anomalies].
Beitr Orthop Traumatol. 1979 Feb ;26(2):80-5.

PubMed
[Muscular glycogenosis. A biochemical study].
[Muscular glycogenosis. A biochemical study].
Ann Anat Pathol (Paris). 1973 Apr-Jun ;18(2):169-94.

PubMed
Dominant language functions of the right hemisphere? Prosody and emotional gestu...
Dominant language functions of the right hemisphere? Prosody and emotional gesturing.
Arch Neurol. 1979 Mar ;36(3):144-8.

PubMed
Dysfunction patterns analogous to frontal lobe system and caudate nucleus syndro...
Dysfunction patterns analogous to frontal lobe system and caudate nucleus syndromes in some groups of minimal brain dysfunction.
J Am Med Womens Assoc. 1973 Jun ;26(6):285-92.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: