Science. 1972 Jul 21;177(4045):279-80.

Fluorescent modification of adenosine 3',5'-monophosphate: spectroscopic properties and activity in enzyme systems.

Secrist JA 3rd, Barrio JR, Leonard NJ, Villar-Palasi C, Gilman AG.

Abstract

The synthesis of a highly fluorescent analog of adenosine 3',5'-monophosphate, namely, 1,N(6)-ethenoadenosine 3',5'-monophosphate, has provided a powerful probe for systems involving adenosine 3',5'-monophosphate. The potential utility of this analog is indicated by its long fluorescent lifetime, detectability at low concentration, and relatively long wavelength of excitation (300 nanometers). In protein kinase systems it is a highly acceptable substitute for adenosine 3',5'-monophosphate.

PMID:: 4339302; [PubMed - indexed for MEDLINE]

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Fluorescent modification of adenosine-containing coenzymes. Biological activities and spectroscopic properties. [Biochemistry. 1972]
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Cited by 10 PubMed Central articles

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