Inhibition of angiotensin I converting enzyme by venom peptides

Br J Pharmacol. 1971 Sep;43(1):252-4. doi: 10.1111/j.1476-5381.1971.tb07176.x.

Abstract

The synthetic analogues of three naturally occurring peptides from the venom of Bothrops jararaca have been tested as inhibitors of angiotensin converting enzyme activity in two systems. They have widely differing absolute potencies but the relative potencies are similar in the two systems. The high inhibitory potency of the nonapeptide is compatible with a non-competitive type of inhibition.

MeSH terms

  • Angiotensin II / antagonists & inhibitors*
  • Animals
  • Drug Synergism
  • Enzyme Inhibitors*
  • Guinea Pigs
  • In Vitro Techniques
  • Lung / enzymology
  • Muscle Contraction / drug effects
  • Peptides / pharmacology
  • Perfusion
  • Protein Conformation
  • Structure-Activity Relationship
  • Venoms / pharmacology*

Substances

  • Enzyme Inhibitors
  • Peptides
  • Venoms
  • Angiotensin II