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J Clin Invest. 1969 Jul;48(7):1273-9.

The role of the liver in the metabolism of vitamin D.


The metabolism of vitamin D(3) has been studied after intravenous injection of 10 IU of [1,2-(3)H]-vitamin D(3) to vitamin D-deficient rats. The disappearance of the radioactivity from the plasma follows a very peculiar pattern characterized by an early rapid disappearance followed by a rebound of radioactivity before assuming still a third rather slow disappearance rate. The "rebound" phenomenon is concomitant with a rapid release of the radioactivity from the liver and is accounted for by the appearance of 25-hydroxycholecalciferol and other metabolites in the blood. It is postulated that the liver is the major site of transformation of vitamin D(3) into 25-hydroxycholecalciferol.

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