Display Settings:

Format

Send to:

Choose Destination
J Lab Clin Med. 1979 Mar;93(3):499-505.

Type IV and type "A-B" collagens do not elicit platelet aggregation or the serotonin release reaction.

Abstract

Human collagens were isolated from kidney, lung, skin, aorta, cartilage, and placenta. Five different types were obtained, including two new molecular species, one characteristic of basement membranes, or type IV collagen, and the other the recently described "A-B" collagen derived from fetal membranes. All the collagens were purified and separated by combination of heat-gelation fractionation and salt fractionation. In neutral solution at 37 degrees neither type IV nor type "A-B" collagen elicited platelet aggregation or 14C-serotonin release. Preincubation of platelets with both types IV and "A-B" collagen did not inhibit aggregation upon subsequent addition of collagen types I, II, or III.

PMID:
429855
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk