J Lab Clin Med. 1979 Feb;93(2):316-20.

Oxygen transport in a woman with hemoglobin Hope/beta+ thalassemia.

Charache S, Achuff S, Winslow R, Kazazian H.

Abstract

Because their blood may "unload" oxygen more readily than normal, people with hemoglobin of low oxygen affinity might be expected to be anemic. We have studied a woman with hemoglobin Hope/beta+ thalassemia, whose hemoglobin level was 10.4 to 12.3 gm/dl (normal 14 +/- 2) despite a P50 of 41 mm Hg (normal 26). Her cardiac index was normal, yielding a calculated mixed venous PO2 of 51 mm Hg (normal 34 to 49). Oxygen transport in patients with low oxygen affinity can be maintained by a variety of homeostatic responses, only one of which is altered erythropoiesis.

PMID:: 429843; [PubMed - indexed for MEDLINE]

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