Gut. 1979 Feb;20(2):169-75.

Peutz-Jeghers syndrome associated with gastrointestinal carcinoma. Report of two cases in a family.

Cochet B, Carrel J, Desbaillets L, Widgren S.

Abstract

Patients with the Peutz-Jeghers syndrome carry a slight, though definite, increased risk of gastrointestinal carcinoma. The malignant potentiality of Peutz-Jeghers hamartomatous polyps, generally considered benign, is supported by this report. Two cases of metastasising gastrointestinal carcinoma associated with the Peutz-Jeghers syndrome are described in a 56 year old female and her 29 year old son. Both mother and son died from duodenal and gastric carcinomas respectively, which developed in hamartomatous polyps with extensive metastases. Both cases also showed dysplastic areas within hamartomatous polyps. These features indicate that hamartomatous polyps may, in some cases, be the precursors of digestive tract carcinomas.

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PMCID:: PMC1419453

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Review [Peutz-Jeghers' syndrome with malignant development in a hamartomatous polyp: report of one case and review of the literature]. [Gastroenterol Clin Biol. 2008]
Review [Peutz-Jeghers' syndrome with malignant development in a hamartomatous polyp: report of one case and review of the literature].
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Cited by 4 PubMed Central articles

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Vasovcák P, Puchmajerová A, Roubalík J, Krepelová A. BMC Med Genet. 2009 Jul 19; 10:69. Epub 2009 Jul 19.
Peutz-Jeghers syndrome and metastasising colonic adenocarcinoma. [Gut. 1984]
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