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1: Gut. 1974 Jan;15(1):34-8.Click here to read Click here to read Links

Carcinoid myopathy and treatment with cyproheptadine (Periactin).

Berry EM, Maunder C, Wilson M.

A case of the carcinoid syndrome associated with a proximal myopathy is reported. Histology showed advanced atrophy of type II muscle fibres but no inflammation. Perinuclear acid phosphatase was increased. Electron microscopy revealed persistence of the Z-line until the muscle fibre had been severely disrupted. Similar lesions have been observed in the hereditary muscular dystrophy in mice, and also in these animals and in rats when injected with 5-hydroxytryptamine (5-HT).Treatment with cyproheptadine caused a documented response in the patient's debilitating diarrhoea and also produced symptomatic improvement in her muscular power. We suggest that the myopathy is due to circulating 5-HT or is a non-metastatic complication of the carcinoid tumour.

PMID: 4274414 [PubMed - indexed for MEDLINE]

PMCID: PMC1412931

Patient Drug Information

  • Cyproheptadine (Periactin® )

    Cyproheptadine relieves red, irritated, itchy, watery eyes; sneezing; and runny nose caused by allergies, irritants in the air, and hay fever. It may also be used to relieve the itching of allergic skin conditions, and t...

  • Source: AHFS Consumer Medication Information