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J Nutr. 1978 May;108(5):779-89.

Effect of peroral administration of xylitol on exocrine secretions of monkeys.


The effects of the administration of xylitol on the biochemical properties of monkey parotid and submandibular saliva and lacrimal fluid were investigated. Monkeys (Macaca mulatta) were fed either a sucrose or xylitol diet for 3 days. Ingestion of xylitol was associated with a significant increase of the activity of the salivary lactoperoxidase. The concentration of protein was also increased. Higher lactoperoxidase activity was found in parotid than in submandibular saliva. The concentrations of inorganic phosphate, calcium and SCN ions were practically unaffected. The concentration of SCN ions in pilocarpine stimulated monkey saliva was low (less than 5.5 mg/liter). Peroral administration of 2.5 g of xylitol or sorbitol per day to M. fascicularis resulted in almost similar levels of salivary lactoperoxidase activity. The administration of xylitol orally or by gastric intubation was not found to affect the concentration of lactoperoxidase, protein, phosphate, and SCN and iodine ions in lacrimal fluid. The results suggest that specific dietary sugars have a selective effect on the biochemical properties of saliva.

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