Biochem Biophys Res Commun. 1985 Nov 27;133(1):248-55.

The human apolipoprotein B-100 gene: a highly polymorphic gene that maps to the short arm of chromosome 2.

Chan L, VanTuinen P, Ledbetter DH, Daiger SP, Gotto AM Jr, Chen SH.

Abstract

Using a cloned cDNA of apolipoprotein B-100 as hydridization probe, we have found high frequence polymorphisms in the apoB-100 gene involving sites for the restriction enzymes EcoRI, BamHI, and HindIII. The major EcoRI polymorphisms involved a 17 kb vs 15 kb variant. The incidence of the various phenotypes was estimated. In addition, other complex polymorphisms involving MspI and TaqI sites were also noted. [32P]-labeled apoB-100 cDNA was used as a probe in chromosome mapping studies to detect the human apoB-100 structural gene sequence in human-Chinese hamster and human-mouse cell hybrids. Southern blot analysis of 14 hybrids localized the gene to the short arm of human chromosome 2.

PMID:: 4074366; [PubMed - indexed for MEDLINE]

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