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Zentralbl Gynakol. 1985;107(20):1249-53.

[Effect of caffeine on fetal heart rate and caffeine consumption habits in pregnant patients].

[Article in German]


Responsiveness to caffeine was studied in early human fetal hearts surviving in nutrient solution. Alterations of the spontaneous contraction rate were followed. Three concentrations (0.01, 0.1 and 1 mmol/l) were applied. In the presence of caffeine there was a significant age- and concentration-dependent increase in fetal heart rate in the period of the 6th to 17th weeks of gestation. Concerning the caffeine consumption habits of pregnant women a questionaire investigation was carried out in 686 cases. 69 per cent of the pregnants regularly drink coffee; 10.7 per cent of them consumes more than 300 mg per day. The authors call attention to the potential harmful effect of caffeine on the fetal heart.

[PubMed - indexed for MEDLINE]
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