Multiple-hole approach to zero-order release

J Pharm Sci. 1985 Sep;74(9):926-33. doi: 10.1002/jps.2600740904.

Abstract

We describe an approach to zero-order drug delivery systems that utilizes a device consisting of multiple holes uniformly distributed in an impermeable membrane. The interior of the device is filled with a suspension of a drug in a polymeric matrix. Near zero-order release is attained by using the proper density and configuration of holes on the surface of the device.

MeSH terms

  • Chemistry, Pharmaceutical
  • Delayed-Action Preparations*
  • Diffusion
  • Solubility

Substances

  • Delayed-Action Preparations