Br J Dermatol. 1985 Sep;113(3):295-301.

Muir-Torre syndrome in several members of a family with a variant of the Cancer Family Syndrome.

Lynch HT, Fusaro RM, Roberts L, Voorhees GJ, Lynch JF.

Abstract

Distinguishing cutaneous signs which are associated with hereditary cancer-prone syndromes are known as cancer-associated genodermatoses. Muir-Torre syndrome (M-T) is characterized by the occurrence of sebaceous hyperplasia, adenoma and carcinoma, basal cell carcinoma with sebaceous differentiation, and/or keratoacanthoma in association with visceral cancer (often multiple), and improved survival. Family studies of M-T have been either wholly lacking or too incomplete to elucidate hereditary aetiology. We describe the cutaneous phenotype of M-T in an extended kindred with a possible variant of the Cancer Family Syndrome. We emphasize the need for more thorough documentation of family histories and cancer association in this cancer-associated genodermatosis in order to clarify hereditary syndrome identification, and to improve cancer control through employment of cutaneous signs as a beacon for highly targeted forms of visceral cancer.

PMID:: 4063166; [PubMed - indexed for MEDLINE]

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Muir-Torre syndrome in several members of a family with a variant of the Cancer Family Syndrome.

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