Derivatives of 4(7)-methyl- and 5,6-dimethyl-benzimidazolyl-2-mercaptoacetic acids

Pol J Pharmacol Pharm. 1977 Jan-Feb;29(1):69-73.

Abstract

Esters, hydrazides and hydrazones of the in title mentioned acids were prepared and screened for tuberculostatic activity. The strongest activity (MIC at 15-6 mug/cm3) was shown by hydrazide 4 and its hydrazone 4a.

MeSH terms

  • Antitubercular Agents / chemical synthesis*
  • Benzimidazoles / chemical synthesis*
  • Benzimidazoles / pharmacology
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis / drug effects
  • Sulfhydryl Compounds / chemical synthesis
  • Sulfhydryl Compounds / pharmacology

Substances

  • Antitubercular Agents
  • Benzimidazoles
  • Sulfhydryl Compounds