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1: Drug Alcohol Depend. 1985 Feb;14(3-4):373-80.Links

Xorphanol.

Howes JF, Villarreal JE, Harris LS, Essigmann EM, Cowan A.

Xorphanol is a new mixed agonist-antagonist from the morphinan class of analgesics. On the basis of animal experiments, the physical dependence liability of xorphanol is predicted to be of a low order in man. Conceptually, xorphanol is of interest since in vitro experiments have revealed anti-naloxone properties and resistance to antagonism by opioid antagonists. At the practical level, xorphanol is a well tolerated, orally active analgesic that provides effective pain relief clinically.

PMID: 4039650 [PubMed - indexed for MEDLINE]

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