Acta Haematol. 1977;57(2):116-20.

Red cell pyruvate kinase deficiency: adverse effect of oral contraceptives.

Abstract

Erythrocyte enzymopathies are being detected with increasing frequency. The homozygous state for pyruvate kinase (PK) deficiency usually causes chronic non-spherocytic haemolytic anaemia. Aggravation of the condition by a variety of extrinsic factors has been reported, but drugs have rarely been incriminated. A case of severe PK deficiency is presented in which an anovulant drug upsets the usual haematologic balance. This strengthens the suspicion that contraceptive pills may be hazardous in such patients.

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Inherited erythrocyte pyruvate kinase deficiency: Studies on 15 members of two related families. [Acta Haematol. 1977]
Inherited erythrocyte pyruvate kinase deficiency: Studies on 15 members of two related families.
Dachà M, Canestrari F, Bossù M, Ferrini PL, Fornaini G. Acta Haematol. 1977; 57(1):37-46.
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