Drug Intell Clin Pharm. 1985 Jun;19(6):431-3.

Hepatitis associated with allopurinol.

Abstract

When adverse reactions occur, it is important to identify the etiologic drug. We describe a case of hepatitis associated with allopurinol. A 66-year-old female was admitted for rehabilitation of a cerebral hemorrhage on September 11, 1981. Allopurinol, clofibrate, and baclofen were administered. Severe hepatitis developed on November 13. The clinical laboratory data returned to normal on November 30. Challenge tests were conducted on clofibrate, allopurinol, and baclofen. The challenge test was positive after the administration of allopurinol. Allopurinol hepatitis is most likely a hypersensitivity reaction, as is suggested by the symptoms of eosinophilia and rash. Renal dysfunction may predispose one to develop hepatitis associated with allopurinol.

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Allopurinol

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Allopurinol-induced granulomatous hepatitis with cholangitis and a sarcoid-like reaction. [Arch Intern Med. 1978]
Allopurinol-induced granulomatous hepatitis with cholangitis and a sarcoid-like reaction.
Swank LA, Chejfec G, Nemchausky BA. Arch Intern Med. 1978 Jun; 138(6):997-8.
[Hypersensitivity syndrome caused by allopurinol. A case of massive hepatic necrosis]. [Rev Invest Clin. 1995]
[Hypersensitivity syndrome caused by allopurinol. A case of massive hepatic necrosis].
González U, Reyes E, Kershenovich J, Orozco-Topete RL. Rev Invest Clin. 1995 Sep-Oct; 47(5):409-13.
[A case of allopurinol-induced granulomatous hepatitis with ductopenia and cholestasis]. [Korean J Hepatol. 2008]
[A case of allopurinol-induced granulomatous hepatitis with ductopenia and cholestasis].
Yoon JY, Min SY, Park JY, Hong SG, Park SJ, Paik SY, Park YM. Korean J Hepatol. 2008 Mar; 14(1):97-101.
Review [Severe acute hepatitis due to allopurinol in a patient with asymptomatic hyperuricemia and kidney failure. A review of the literature and an analysis of the risk factors]. [Gastroenterol Hepatol. 1997]
Review [Severe acute hepatitis due to allopurinol in a patient with asymptomatic hyperuricemia and kidney failure. A review of the literature and an analysis of the risk factors].
Andrade RJ, de la Mata M, Lucena MI, López-Rubio F, Corrales MA. Gastroenterol Hepatol. 1997 Aug-Sep; 20(7):353-6.
Review Allopurinol hypersensitivity syndrome: a review. [Ann Pharmacother. 1993]
Review Allopurinol hypersensitivity syndrome: a review.
Arellano F, Sacristán JA. Ann Pharmacother. 1993 Mar; 27(3):337-43.

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Cited by 1 PubMed Central article

Use and abuse of allopurinol. [Br Med J (Clin Res Ed). 1987]
Use and abuse of allopurinol.
Cameron JS, Simmonds HA. Br Med J (Clin Res Ed). 1987 Jun 13; 294(6586):1504-5.

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