The effects of capsaicin applied to the exposed ventral surface of the medulla were studied on the mean arterial blood pressure, heart rate, respiration and sympathetic efferent nerve activity in chloralose-urethane-anaesthetized cats. The application of capsaicin produced a marked increase in the mean arterial blood pressure and sympathetic nerve activity, but not in the heart rate. The "intermediate area" proved to be the most sensitive to capsaicin. Pressor responses could be elicited repeatedly; tachyphylaxis was not noted provided a time interval of 30 min elapsed between consecutive applications. Repeated applications of capsaicin at intervals of less than 30 min led to tachyphylaxis. However, pressor responses evoked by either topical application of glutamate or pentamethylene-tetrazole or bilateral carotid occlusion could invariably be demonstrated during this period of tachyphylaxis. Histological studies revealed the existence of a hitherto unrecognized termination of capsaicin-sensitive nerve endings within the ventral medullary chemosensitive area of the cat. The results provide both functional and morphological evidence for the presence of a capsaicin-sensitive vasomotor mechanism in the ventral medullary chemo-sensitive area of the cat. It is suggested that the pressor effects of capsaicin applied to the ventral medullary chemo-sensitive area may be mediated by an activation of capsaicin-sensitive primary sensory afferents terminating in this area. Accordingly, capsaicin-sensitive neuronal mechanisms located in the ventral medullary chemosensitive area may play an important role in the central nervous regulation of blood pressure.