Jpn J Pharmacol. 1985 Mar;37(3):300-2.

Effect of idebenone (CV-2619) on memory impairment observed in passive avoidance task in rats with cerebral embolization.

Kiyota Y, Hamajo K, Miyamoto M, Nagaoka A.

Abstract

Effect of idebenone (CV-2619) on memory impairment was studied in rats with cerebral embolization. The cerebral embolization, produced by injecting 2000 microspheres into the internal carotid artery, caused a significant impairment in passive avoidance response. Repeated administrations of idebenone (30 mg/kg/day, i.p.), partially but significantly improved the impairment of the passive avoidance response in the embolized rats. The results suggest that the repeated administration of idebenone exerts an ameliorating effect on memory impairment induced by cerebral embolization.

PMID:: 3999479; [PubMed - indexed for MEDLINE]

Free full text

LinkOut - more resources

Supplemental Content

Save items

Related citations in PubMed

Effects of idebenone on memory impairment induced in ischemic and embolization models of cerebrovascular disturbance in rats. [Arch Gerontol Geriatr. 1989]
Effects of idebenone on memory impairment induced in ischemic and embolization models of cerebrovascular disturbance in rats.
Yamazaki N, Kiyota Y, Take Y, Miyamoto M, Nagawa Y, Nagaoka A. Arch Gerontol Geriatr. 1989 May; 8(3):213-24.
Beneficial effect of idebenone (CV-2619) on cerebral ischemia-induced amnesia in rats. [Jpn J Pharmacol. 1984]
Beneficial effect of idebenone (CV-2619) on cerebral ischemia-induced amnesia in rats.
Yamazaki N, Take Y, Nagaoka A, Nagawa Y. Jpn J Pharmacol. 1984 Nov; 36(3):349-56.
[Ameliorating effects of idebenone and indeloxazine hydrochloride on impairment of radial maze learning in cerebral embolized rats]. [Nihon Yakurigaku Zasshi. 1989]
[Ameliorating effects of idebenone and indeloxazine hydrochloride on impairment of radial maze learning in cerebral embolized rats].
Kiyota Y, Miyamoto M, Nagaoka A. Nihon Yakurigaku Zasshi. 1989 Mar; 93(3):197-202.
Review Inhibition of brain mitochondrial swelling by idebenone. [Arch Gerontol Geriatr. 1989]
Review Inhibition of brain mitochondrial swelling by idebenone.
Suno M, Nagaoka A. Arch Gerontol Geriatr. 1989 May; 8(3):299-305.
Review [Vasopressin and the mechanisms of memory. The problems under discussion]. [Nerv Sist. 1991]
Review [Vasopressin and the mechanisms of memory. The problems under discussion].
Ashmarin IP, Titov SA. Nerv Sist. 1991; 30:3-27.

See reviews... See all...

Cited by 4 PubMed Central articles

Review Reactive oxygen species in the regulation of synaptic plasticity and memory. [Antioxid Redox Signal. 2011]
Review Reactive oxygen species in the regulation of synaptic plasticity and memory.
Massaad CA, Klann E. Antioxid Redox Signal. 2011 May 15; 14(10):2013-54. Epub 2010 Oct 28.
Vanilloid VR1 receptor is involved in rimonabant-induced neuroprotection. [Br J Pharmacol. 2006]
Vanilloid VR1 receptor is involved in rimonabant-induced neuroprotection.
Pegorini S, Zani A, Braida D, Guerini-Rocco C, Sala M. Br J Pharmacol. 2006 Mar; 147(5):552-9.
Capsaicin exhibits neuroprotective effects in a model of transient global cerebral ischemia in Mongolian gerbils. [Br J Pharmacol. 2005]
Capsaicin exhibits neuroprotective effects in a model of transient global cerebral ischemia in Mongolian gerbils.
Pegorini S, Braida D, Verzoni C, Guerini-Rocco C, Consalez GG, Croci L, Sala M. Br J Pharmacol. 2005 Mar; 144(5):727-35.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Effect of idebenone (CV-2619) on memory impairment observed in passive avoidance...
Effect of idebenone (CV-2619) on memory impairment observed in passive avoidance task in rats with cerebral embolization.
Jpn J Pharmacol. 1985 Mar ;37(3):300-2.

PubMed
Carcinoma of the penis: analysis of 192 consecutive cases at the Instituto Nacio...
Carcinoma of the penis: analysis of 192 consecutive cases at the Instituto Nacional de Enfermedades Neoplasicas.
Int Adv Surg Oncol. 1979 ;2:201-21.

PubMed
Cigarette smoking associated with delayed conception.
Cigarette smoking associated with delayed conception.
JAMA. 1985 May 24-31 ;253(20):2979-83.

PubMed
Protein degradation in metabolic and nutritional disorders.
Protein degradation in metabolic and nutritional disorders.
Ciba Found Symp. 1979 ;(75):331-50.

PubMed
Follow-up investigation in patients with anorexia nervosa.
Follow-up investigation in patients with anorexia nervosa.
J Pediatr. 1985 May ;106(5):835-40.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Effect of idebenone (CV-2619) on memory impairment observed in passive avoidance task in rats with cerebral embolization.

Abstract

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 4 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information