Format

Send to:

Choose Destination
See comment in PubMed Commons below
Control Clin Trials. 1985 Mar;6(1):25-37.

Curtailed binomial sampling procedures for clinical trials with paired data.

Abstract

The use of curtailed sampling procedures in designing clinical trials with a dichotomous response and paired data is reviewed. Tables of expected sample size savings and a simple to evaluate asymptotic formula for the expected sample size savings are presented where the sample size savings is calculated relative to the fixed sample size test. Comparisons are made among fixed sample size, curtailed, and repeated significance hypothesis testing procedures. In view of the substantial savings in sample size available under certain conditions and the accuracy of the approximating formula, it is recommended that curtailed procedures be given serious consideration in the design of clinical trials.

PMID:
3987301
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk