Scopolamine, morphine, and brain-stem auditory evoked potentials in awake monkeys

Anesthesiology. 1985 Apr;62(4):437-41. doi: 10.1097/00000542-198504000-00011.

Abstract

The effects of scopolamine and morphine sulfate on brain-stem auditory evoked potentials (BAEPs) were studied in 10 rhesus (Macaca mulatta) monkeys. Study drugs were given intravenously to unanesthetized animals and BAEPs recorded at 3-min and 30-min intervals after administration of 0.1 mg/kg and 0.32 mg/kg of scopolamine and 15 min after administration of 3.2 mg/kg morphine at the end of the experiment. No significant change in either latency or amplitude of different components of BAEPs was observed.

MeSH terms

  • Animals
  • Behavior, Animal / drug effects
  • Brain Stem / drug effects
  • Dose-Response Relationship, Drug
  • Electroencephalography
  • Evoked Potentials, Auditory / drug effects*
  • Female
  • Macaca mulatta
  • Male
  • Morphine / pharmacology*
  • Reaction Time / drug effects
  • Scopolamine / pharmacology*

Substances

  • Morphine
  • Scopolamine