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    Arzneimittelforschung. 1979;29(9a):1483-5.

    Creatinol O-phosphate therapy in patients with inadequate coronary circulation. Double-blind clinical trial.

    Barlattani M, Guglielmi G, Mammarella A.

    N-Methyl-N-(beta-hydroxyethyl) guanidine O-phosphate (creatinol O-phosphate, COP) was checked on patients suffering from inadequate coronary circulation (12 patients had a recent myocardial infarction and 13 were suffering from angina pectoris) versus a reference substance (solvent of COP) in a double blind study. COP improved rhythm disturbances, chest pains and symptoms of contractility failure to a statistically significant degree.

    PMID: 395958 [PubMed - indexed for MEDLINE]

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