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    Comp Biochem Physiol B. 1986;83(3):681-4.

    Effect of triiodothyronine on intestinal and kidney isoenzymes of alkaline phosphatase and on vitamin D metabolism in adult female rats.

    Colston K, Cleeve HJ.

    Adult female Wistar rats receiving normal or vitamin D restricted diet were made thyrotoxic by subcutaneous injection of T3. T3 treatment enhanced intestinal alkaline phosphatase activity and augmented the stimulatory effect of vitamin D on the enzyme in this tissue. In kidney, T3 treatment lead to a decrease in alkaline phosphatase activity in normal, vitamin D restricted and vitamin D repleted rats. The conversion of 25OHD3 to 24,25(OH)2D3 in vivo was enhanced in thyrotoxic rats. These results suggest an interaction between the thyroid and vitamin D endocrine systems.

    PMID: 3956179 [PubMed - indexed for MEDLINE]

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